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KMID : 1161520200240040214
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Animal Cells and Systems
2020 Volume.24 No. 4 p.214 ~ p.219
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Capsaicin suppresses liver fat accumulation in high-fat diet-induced NAFLD mice
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Shin Mi-Kyung
Yang Soo-Man
Han In-Seob
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Abstract
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Dietary capsaicin exhibits anti-steatosis activity in obese mice. High-fat diet (HFD)-induced mice is a highly studied approach to develop non-alcoholic fatty liver disease (NAFLD). In this study, we determined whether the topical application of capsaicin can improve lesions of NAFLD. The HFD-induced mice were treated with daily topical application of capsaicin for 8 weeks. Topical application of capsaicin reduced liver fat in HFD-fed mice. Capsaicin stimulated carnitine palmitoyl transferase (CPT)-1 and CD36 expression, which are associated with β-oxidation and fatty acids influx of liver while it decreased the expression of key enzymes involved in the synthesis of fatty acids, such as acetyl Co-A carboxylase (ACC) and fatty acid synthase (FAS). Immunohistochemical analysis revealed the elevated level of adiponectin in liver tissue of the capsaicin-treated mice. These results suggest that the topical application of capsaicin suppresses liver fat accumulation through the upregulation of β-oxidation and de novo lipogenesis in HFD-induced NAFLD mice.
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KEYWORD
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Capsaicin, high-fat diet (HFD), NAFLD, fatty acid, metabolism
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